Key takeaways Some of the largest trials of popular supplements found no clear benefit in healthy adults. A handful are worth considering when there is a specific reason: a low blood level, a training goal, a dietary gap. Multivitamins, high-dose antioxidants, resveratrol and NAD+ boosters have the weakest case for "longevity". Sleep, strength training, protein and a Mediterranean-style diet outperform any capsule. Educational content only. Not medical advice. Scroll any feed